Speaker
Description
We address the two-fold applicability of the power spectrum density of the large-conductance voltage- and Ca2+ -activated potassium channels of the inner mitochondrial membrane (mitoBK). First, we will address the estimation of the optimal sampling frequency for the fibroblast's mitoBK patch-clamp data analysis [1], employing the process with doubly harmonic diminution, known to produce pink noise [2]. Next, we will discuss the ion current's empirical modes [3] in detail. We will show that the consecutive mode's power spectra show known 1/f characteristics. The brief correspondence of the instantaneous frequencies to the actual time scales will also be presented.
[1] L. Machura, A. Wawrzkiewicz-Jałowiecka, P. Bednarczyk, and P. Trybek, Linking the Sampling Frequency with Multiscale Entropy to classify mitoBK patch-clamp data, Biomed. Signal. Process. Control 76, 103680 (2022).
[2] P.M. Riechers, J.P. Crutchfield, Fraudulent white noise: Flat power spectra belie arbitrarily complex processes, Phys. Rev. Res. 3 013170 (2021).
[3] N.E. Huang et al., The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis, Proc. R. Soc. Lond. A 454.1971 (1998).
