18-21 September 2019
Kraków
Europe/Warsaw timezone

Modeling of living cell’s mechanical properties

Not scheduled
15m
Kraków

Kraków

Poster

Speaker

Agnieszka Kurek (Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences)

Description

Cell’s mechanical and physical properties such as elasticity or adhesion are significant parameters determining cell behaviour [1].
Changes in mechanical properties of cells can be connected with diseases such as cancer or blood diseases. Quantification of mechanical properties, analysis and comparison of collected data, can allow understanding the mechanism of disease formation and development [2].
Many technique can be used to measure single cells or tissues properties. One of commonly used technique is Atomic Force Microscopy. Thought interaction between sample surface and tip measurement, AFM allow to create single living cell mapping [2].
Another way to understand cell behaviour is computer modelling of cell response in indentation experiments [3]. In literature many authors describe variety of models, which base on divers physical lows and for this reason have different restrictions [4]. In our poster we present a few models which are commonly used to description and modelling of cell properties.

References:
1. Carl, P. & Schillers, H. Elasticity measurement of living cells with an atomic force microscope: Data acquisition and processing. Pflugers Arch. Eur. J. Physiol. 457, 551–559 (2008).
2. Rianna, C. & Radmacher, M. Cell mechanics as a marker for diseases: Biomedical applications of AFM. AIP Conf. Proc. 1760, (2016).
3. Liu, Y., Mollaeian, K. & Ren, J. Finite element modeling of living cells for AFM indentation-based biomechanical characterization. Micron 116, 108–115 (2019).
4. Guz, N., Dokukin, M., Kalaparthi, V. & Sokolov, I. If Cell Mechanics Can Be Described by Elastic Modulus: Study of Different Models and Probes Used in Indentation Experiments. Biophys. J. 107, 564–575 (2014).

Primary authors

Agnieszka Kurek (Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences) Dr. Leszek Krzemień (Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences) Dr. Jakub Barbasz (Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences)

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