We discuss the dynamics of major genetic forces that shape evolution of cancer cells, using mathematics of stochastic processes. A range of biological examples will serve to illustrate the methodology, including leukemias and other hematological syndromes as well as solid neoplasia, such as lung, breast and bladder cancers. The latter example will help illustrate the notion of the field...
The recent expansion of single-cell sequencing technologies has enabled simultaneous genome-wide measurements of multiple modalities in the same single cell. The potential to jointly profile such modalities as gene expression, chromatin accessibility, proteins, or multiple histone modifications at single-cell resolution represents a compelling opportunity to study biological processes at...
The radiation adaptive response (or radioadaptiation) effect is a biophysical and radiobiological phenomenon responsible for e.g. the enhancement of repair processes, cell cycle and apoptosis regulation or enhancement of antioxidant production in cells / organisms irradiatied by low doses and low dose-rates of ionising radiation. Here we propose a comprehensive and complete theoretical model...
